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BARD1 Participates with BRCA1 in Homology-Directed Repair of Chromosome Breaks

15 Oct 2003

Abstract excerpt

The BRCA1 tumor suppressor has been implicated in the maintenance of chromosomal stability through homology-directed repair of DNA double-strand breaks. Much of the BRCA1 in cells forms a heterodimeric complex with a structurally related protein BARD1. We report that expression of truncated mouse or human BARD1 peptides capable of interacting with Brca1 results in a homologous-repair deficiency. Repair is mildly...

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PMID: 14560035
DOI: 10.1128/mcb.23.21.7926-7936.2003

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