Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical and Genetic Risk Prediction of Subsequent CNS Tumors in Survivors of Childhood Cancer: A Report From the COG ALTE03N1 Study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Nov 2017

Wang Xuexia, Sun Can-Lan, Hageman Lindsey, Smith Kandice, Singh Purnima, Desai Sunil, Hawkins Douglas S, Hudson Melissa M, Mascarenhas Leo, Neglia Joseph P, Oeffinger Kevin C, Ritchey A Kim, Robison Leslie L, Villaluna Doojduen, Landier Wendy, Bhatia Smita

Abstract excerpt

Purpose Survivors of childhood cancer treated with cranial radiation therapy are at risk for subsequent CNS tumors. However, significant interindividual variability in risk suggests a role for genetic susceptibility and provides an opportunity to identify survivors of childhood cancer at increased risk for these tumors. Methods We curated candidate genetic variants from previously published studies in adult-onset...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Central Nervous System Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Ligase ATP

Share to DNA Polymerase III

Share to Endonucleases

Share to Genes, BRCA2

Share to Neoplasms, Radiation-Induced

Share to X-ray Repair Cross Complementing Protein 1

Source

Open in PubMed Open full text

Identifiers

PMID: 28976792
DOI: 10.1200/JCO.2017.74.7444
PMCID: PMC5678343

Genes

BRCA2
ERCC1
LIG4
POLD1
XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical and Genetic Risk Prediction of Subsequent CNS Tumors in Survivors of Childhood Cancer: A Report From the COG ALTE03N1 Study.PMID 28976792Read ↗

Genetic Risk of Second Malignant Neoplasm after Childhood Cancer Treatment: A Systematic Review.Semantic proximity Read ↗

Germline rare variants in cancer susceptibility genes and subsequent neoplasm risk after childhood cancer.Semantic proximity Read ↗

Genetic Risk for Subsequent Neoplasms Among Long-Term Survivors of Childhood Cancer.Semantic proximity Read ↗

Germline Pathogenic/Likely Pathogenic Mutations and Subsequent Neoplasms Among Childhood Cancer Survivors: A Report From the Children's Oncology Group ALTE03N1 Study.Semantic proximity Read ↗

Genetic Predictors of Neurocognitive Outcomes in Survivors of Pediatric Brain TumorsSemantic proximity Read ↗

Germline genetic landscape of pediatric central nervous system tumors.Semantic proximity Read ↗

Estimated number of adult survivors of childhood cancer in United States with cancer-predisposing germline variants.Semantic proximity Read ↗

Genome-Wide Association Study to Identify Susceptibility Loci That Modify Radiation-Related Risk for Breast Cancer After Childhood Cancer.Semantic proximity Read ↗

Update on Cancer Predisposition Syndromes and Surveillance Guidelines for Childhood Brain Tumors.Semantic proximity Read ↗

Contributions of cancer treatment and genetic predisposition to risk of subsequent neoplasms in long-term survivors of childhood cancer: a report from the St Jude Lifetime Cohort and the Childhood Cancer Survivor Study.Semantic proximity Read ↗

Subsequent neoplasms of the CNS among survivors of childhood cancer: a systematic review.Semantic proximity Read ↗

Therapy-Related Mutational Signatures in Subsequent Neoplasms among Survivors of Childhood Cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.