Monoallelic BRCA1/2 variants in pediatric, adolescent, and young adult patients with central nervous system tumors.

doi:10.1016/j.esmoop.2026.108252

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Article

Monoallelic BRCA1/2 variants in pediatric, adolescent, and young adult patients with central nervous system tumors.

ESMO open - 1 Aug 2026

Cipri S, Agolini E, Baldo G D, Cacchione A, Megaro G, Rossi S, Barresi S, Carai A, Colafati G S, Boccuto L, Mastronuzzi A

Abstract excerpt

BACKGROUND: Alterations in the BRCA1 DNA repair associated (BRCA1) and BRCA2 DNA repair associated (BRCA2), two key DNA repair genes, are strongly linked to adult-onset malignancies and play a significant role in tumor development. Although BRCA1 and BRCA2 are firmly recognized as hereditary cancer risk genes in adult populations, their role in central nervous system (CNS) tumor susceptibility in younger patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42462279
DOI: 10.1016/j.esmoop.2026.108252
PMCID: PMC13400398

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.