Article
An essential role for IGF2 in cartilage development and glucose metabolism during postnatal long bone growth.
Development (Cambridge, England) - 1 Oct 2017
Uchimura Tomoya, Hollander Judith M, Nakamura Daisy S, Liu Zhiyi, Rosen Clifford J, Georgakoudi Irene, Zeng Li
Abstract excerpt
Postnatal bone growth involves a dramatic increase in length and girth. Intriguingly, this period of growth is independent of growth hormone and the underlying mechanism is poorly understood. Recently, an IGF2 mutation was identified in humans with early postnatal growth restriction. Here, we show that IGF2 is essential for longitudinal and appositional murine postnatal bone development, which involves proper...
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