Article

Tmem263 deletion disrupts the GH/IGF-1 axis and causes dwarfism and impairs skeletal acquisition

2023-08-03

Abstract excerpt

<h4>ABSTRACT</h4> Genome-wide association studies (GWAS) have identified a large number of candidate genes believed to affect longitudinal bone growth and bone mass. One of these candidate genes, TMEM263 , encodes a poorly characterized plasma membrane protein. Single nucleotide polymorphisms in TMEM263 are associated with bone mineral density in humans and mutations are associated with dwarfism in chicken and s...

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Literature Corpus work: 7bf2a471-72c0-5b1a-88b1-2dc4ee600e6d
DOI: 10.1101/2023.08.02.551694

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