Article
Mechanistic insights into the effect of CYP2C9*2 and CYP2C9*3 variants on the 7-hydroxylation of warfarin.
Pharmacogenomics - 1 Jan 2015
Pavani Addepalli, Naushad Shaik Mohammad, Stanley Balraj Alex, Kamakshi Renganathan Gnanambal, Abinaya Krishnan, Amaresh Rao Malempati, Uma Addepally, Kutala Vijay Kumar
Abstract excerpt
AIM: To evaluate the impact of CYP2C9*2 and CYP2C9*3 variants on binding and hydroxylation of warfarin. MATERIALS & METHODS: Multiple linear regression model of warfarin pharmacokinetics was developed from the dataset of patients (n = 199). Pymol based in silico models were developed for the genetic variants. RESULTS: CYP2C9*2 and CYP2C9*3 variants exhibited high warfarin/7-hydroxywarfarin (multiple linear...
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