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Article

Plk4 and Aurora A cooperate in the initiation of acentriolar spindle assembly in mammalian oocytes

28 Sept 2017

Abstract excerpt

Establishing the bipolar spindle in mammalian oocytes after their prolonged arrest is crucial for meiotic fidelity and subsequent development. In contrast to somatic cells, the first meiotic spindle assembles in the absence of centriole-containing centrosomes. Ran-GTP can promote microtubule nucleation near chromatin, but additional unidentified factors are postulated for the activity of multiple acentriolar...

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PMID: 28972102
DOI: 10.1083/jcb.201606077

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