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Article

Actin-microtubule interplay coordinates spindle assembly in human oocytes

11 Oct 2019

Abstract excerpt

Mammalian oocytes assemble a bipolar acentriolar microtubule spindle to segregate chromosomes during asymmetric division. There is increasing evidence that actin in the spindle interior not only participates in spindle migration and positioning but also protects oocytes from chromosome segregation errors leading to aneuploidy. Here we show that actin is an integral component of the meiotic machinery that closely...

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PMID: 31604948
DOI: 10.1038/s41467-019-12674-9

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