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Article

Error-prone meiotic division and subfertility in mice with oocyte-conditional knockdown of pericentrin

13 Feb 2017

Abstract excerpt

Mouse oocytes lack canonical centrosomes and instead contain unique acentriolar microtubule-organizing centers (aMTOCs). To test the function of these distinct aMTOCs in meiotic spindle formation, pericentrin (Pcnt), an essential centrosome/MTOC protein, was knocked down exclusively in oocytes by using a transgenic RNAi approach. Here, we provide evidence that disruption of aMTOC function in oocytes promotes...

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PMID: 28193732
DOI: 10.1242/jcs.196188

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