Article
A mouse-to-man candidate gene study identifies association of chronic otitis media with the loci TGIF1 and FBXO11.
Scientific reports - 2 Oct 2017
Bhutta Mahmood F, Lambie Jane, Hobson Lindsey, Goel Anuj, Hafrén Lena, Einarsdottir Elisabet, Mattila Petri S, Farrall Martin, Brown Steve, Burton Martin J
Abstract excerpt
Chronic otitis media with effusion (COME) is the most common cause of hearing loss in children, and known to have high heritability. Mutant mouse models have identified Fbxo11, Evi1, Tgif1, and Nisch as potential risk loci. We recruited children aged 10 and under undergoing surgical treatment for COME from 35 hospitals in the UK, and their nuclear family. We performed association testing with the loci FBXO11,...
Topics
- Alleles
- Animals
- Child
- Child, Preschool
- Chronic Disease
- Cohort Studies
- Disease Models, Animal
- F-Box Proteins
- Female
- Gene Expression
- Genetic Loci