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Article

Otitis media in the Tgif knockout mouse implicates TGFβ signalling in chronic middle ear inflammatory disease.

Human molecular genetics - 1 Jul 2013

Tateossian Hilda, Morse Susan, Parker Andrew, Mburu Philomena, Warr Nick, Acevedo-Arozena Abraham, Cheeseman Michael, Wells Sara, Brown Steve D M

Abstract excerpt

Otitis media with effusion (OME) is the most common cause of hearing loss in children and tympanostomy to alleviate the condition remains the commonest surgical intervention in children in the developed world. Chronic and recurrent forms of OM are known to have a very significant genetic component, however, until recently little was known of the underlying genes involved. The identification of mouse models of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23459932
DOI: 10.1093/hmg/ddt103
PMCID: PMC3674796

Genes

SMAD2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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