Article
FBXO11, a regulator of the TGFβ pathway, is associated with severe otitis media in Western Australian children.
Genes and immunity - 1 Jul 2011
Rye M S, Wiertsema S P, Scaman E S H, Oommen J, Sun W, Francis R W, Ang W, Pennell C E, Burgner D, Richmond P, Vijayasekaran S, Coates H L, Brown S D, Blackwell J M, Jamieson S E
Abstract excerpt
Otitis media (OM) is a common childhood disease characterised by middle ear inflammation following infection. Susceptibility to recurrent acute OM (rAOM) and chronic OM with effusion (COME) is highly heritable. Two murine mutants, Junbo and Jeff, spontaneously develop severe OM with similar phenotypes to human disease. Fine-mapping of these mutants identified two genes (Evi1 and Fbxo11) that interact with the...
Topics
- Alleles
- Australia
- Child
- Child, Preschool
- DNA-Binding Proteins
- F-Box Proteins
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Linkage Disequilibrium