Article
A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways.
PLoS genetics - 1 Aug 2017
Crompton Michael, Purnell Tom, Tyrer Hayley E, Parker Andrew, Ball Greg, Hardisty-Hughes Rachel E, Gale Richard, Williams Debbie, Dean Charlotte H, Simon Michelle M, Mallon Ann-Marie, Wells Sara, Bhutta Mahmood F, Burton Martin J, Tateossian Hilda, Brown Steve D M
Abstract excerpt
Otitis media (OM), inflammation of the middle ear (ME), is a common cause of conductive hearing impairment. Despite the importance of the disease, the aetiology of chronic and recurrent forms of middle ear inflammatory disease remains poorly understood. Studies of the human population suggest that there is a significant genetic component predisposing to the development of chronic OM, although the underlying genes...
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