Article
Genome-wide association study to identify the genetic determinants of otitis media susceptibility in childhood.
PloS one - 1 Jan 2012
Rye Marie S, Warrington Nicole M, Scaman Elizabeth S H, Vijayasekaran Shyan, Coates Harvey L, Anderson Denise, Pennell Craig E, Blackwell Jenefer M, Jamieson Sarra E
Abstract excerpt
BACKGROUND: Otitis media (OM) is a common childhood disease characterised by middle ear inflammation and effusion. Susceptibility to recurrent acute OM (rAOM; ≥ 3 episodes of AOM in 6 months) and chronic OM with effusion (COME; MEE ≥ 3 months) is 40-70% heritable. Few underlying genes have been identified to date, and no genome-wide association study (GWAS) of OM has been reported. METHODS AND FINDINGS: Data for...
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