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Article

Otitis media in a new mouse model for CHARGE syndrome with a deletion in the Chd7 gene.

PloS one - 1 Jan 2012

Tian Cong, Yu Heping, Yang Bin, Han Fengchan, Zheng Ye, Bartels Cynthia F, Schelling Deborah, Arnold James E, Scacheri Peter C, Zheng Qing Yin

Abstract excerpt

Otitis media is a middle ear disease common in children under three years old. Otitis media can occur in normal individuals with no other symptoms or syndromes, but it is often seen in individuals clinically diagnosed with genetic diseases such as CHARGE syndrome, a complex genetic disease caused by mutation in the Chd7 gene and characterized by multiple birth defects. Although otitis media is common in human...

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Identifiers

PMID: 22539951
DOI: 10.1371/journal.pone.0034944
PMCID: PMC3335168

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Otitis media in a new mouse model for CHARGE syndrome with a deletion in the Chd7 gene.PMID 22539951Read ↗

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The chromatin remodeling protein CHD7, mutated in CHARGE syndrome, is necessary for proper craniofacial and tracheal developmentSemantic proximity Read ↗

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