Article
Unraveling the genetics of otitis media: from mouse to human and back again.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 2011
Rye Marie S, Bhutta Mahmood F, Cheeseman Michael T, Burgner David, Blackwell Jenefer M, Brown Steve D M, Jamieson Sarra E
Abstract excerpt
Otitis media (OM) is among the most common illnesses of early childhood, characterised by the presence of inflammation in the middle ear cavity. Acute OM and chronic OM with effusion (COME) affect the majority of children by school age and have heritability estimates of 40-70%. However, the majority of genes underlying this susceptibility are, as yet, unidentified. One method of identifying genes and pathways...
Topics
- Animals
- Disease Models, Animal
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Mice
- Otitis Media