Article
A mutation in the F-box gene, Fbxo11, causes otitis media in the Jeff mouse.
Human molecular genetics - 15 Nov 2006
Hardisty-Hughes Rachel E, Tateossian Hilda, Morse Susan A, Romero M Rosario, Middleton Alice, Tymowska-Lalanne Zuzanna, Hunter A Jackie, Cheeseman Michael, Brown Steve D M
Abstract excerpt
Otitis media (OM), inflammation of the middle ear, is the most common cause of hearing impairment and surgery in children. Recurrent and chronic forms of OM are known to have a strong genetic component, but nothing is known of the underlying genes involved in the human population. We have previously identified a novel semi-dominant mouse mutant, Jeff, in which the heterozygotes develop chronic suppurative OM...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- F-Box Proteins
- Homozygote
- Mice
- Molecular Sequence Data
- Mutation
- Otitis Media
- Phenotype
- Proteins