Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Control of HIV-1 by an HLA-B52:01-C12:02 Protective Haplotype.

The Journal of infectious diseases - 12 Dec 2017

Chikata Takayuki, Murakoshi Hayato, Koyanagi Madoka, Honda Kazutaka, Gatanaga Hiroyuki, Oka Shinichi, Takiguchi Masafumi

Abstract excerpt

HLA-B*52:01-C*12:02, which is found in approximately 20% of all Japanese persons, is well known to be associated with ulcerative colitis and Takayasu arteritis. This haplotype is also known to be protective in individuals infected with human immunodeficiency virus (HIV) type 1. Recent studies showed that HLA-B*52:01-restricted HIV-1-specific T cells suppress HIV-1 and that HLA-C*12:02 together with KIR2DL2 play...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromium
Share to Epitopes, T-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-C Antigens

Share to Immunodominant Epitopes

Share to nef Gene Products, Human Immunodeficiency Virus

Share to pol Gene Products, Human Immunodeficiency Virus

Share to Receptors, KIR2DL2

Share to T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 28968792
DOI: 10.1093/infdis/jix483

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Control of HIV-1 by an HLA-B*52:01-C*12:02 Protective Haplotype.PMID 28968792Read ↗

Clinical Control of HIV-1 by Cytotoxic T Cells Specific for Multiple Conserved EpitopesSemantic proximity Read ↗

Accumulation of Pol Mutations Selected by HLA-B*52:01-C*12:02 Protective Haplotype-Restricted Cytotoxic T Lymphocytes Causes Low Plasma Viral Load Due to Low Viral Fitness of Mutant Viruses.Semantic proximity Read ↗

HIV-1 Control by NK Cells via Reduced Interaction between KIR2DL2 and HLA-C∗12:02/C∗14:03.Semantic proximity Read ↗

Immunological Control of HIV-1 Disease Progression by Rare Protective HLA Allele.Semantic proximity Read ↗

Long-term control of HIV-1 in hemophiliacs carrying slow-progressing allele HLA-B*5101.Semantic proximity Read ↗

HLA-B may be more protective against HIV-1 than HLA-A because it resists negative regulatory factor (Nef) mediated down-regulation.Semantic proximity Read ↗

Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences.Semantic proximity Read ↗

Host-specific adaptation of HIV-1 subtype B in the Japanese population.Semantic proximity Read ↗

HIV-1 Vpu Mediates HLA-C Downregulation.Semantic proximity Read ↗

HLA Class I-Mediated HIV-1 Control in Vietnamese Infected with HIV-1 Subtype A/E.Semantic proximity Read ↗

Naturally arising HIV-1 Nef variants conferring escape from cytotoxic T lymphocytes influence viral entry co-receptor expression and susceptibility to superinfection.Semantic proximity Read ↗

Selection of escape mutation by Pol154-162-specific cytotoxic T cells among chronically HIV-1-infected HLA-B*5401-positive individuals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.