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Article

The RFC1 80G>A, among Common One-Carbon Polymorphisms, Relates to Survival Rate According to DNA Global Methylation in Primary Liver Cancers.

PloS one - 1 Jan 2016

Moruzzi Sara, Udali Silvia, Ruzzenente Andrea, Guglielmi Alfredo, Guarini Patrizia, Martinelli Nicola, Conci Simone, Mazzi Filippo, Pattini Patrizia, Tammen Stephanie A, Olivieri Oliviero, Pizzolo Francesca, Choi Sang-Woon, Friso Simonetta

Abstract excerpt

Polymorphisms within one-carbon metabolism genes have been largely studied in relation to cancer risk for the function of this pathway in nucleotide synthesis and DNA methylation. Aims of this study were to explore the possible link among several common functional gene polymorphisms within one-carbon metabolism and survival rate in primary liver cancers, i.e., hepatocellular carcinoma and cholangiocarcinoma, and...

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Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Kaplan-Meier Estimate

Share to Leukocytes, Mononuclear

Share to Proportional Hazards Models

Share to Reduced Folate Carrier Protein

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Source

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Identifiers

PMID: 27936032
DOI: 10.1371/journal.pone.0167534
PMCID: PMC5147923

Genes

RFC1
BHMT
DHFR
MTHFD1
MTHFR
MTR
MTRR
SHMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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