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Article

Evaluation of four KCNMA1 channelopathy variants on BK channel current under CaV1.2 activation.

Channels (Austin, Tex.) - 1 Dec 2024

Dinsdale Ria L, Meredith Andrea L

Abstract excerpt

Variants in KCNMA1, encoding the voltage- and calcium-activated K+ (BK) channel, are associated with human neurological disease. The effects of gain-of-function (GOF) and loss-of-function (LOF) variants have been predominantly studied on BK channel currents evoked under steady-state voltage and Ca2+ conditions. However, in their physiological context, BK channels exist in partnership with voltage-gated Ca2+...

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Source

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Identifiers

PMID: 39217512
DOI: 10.1080/19336950.2024.2396346
PMCID: PMC11370921

Genes

KCNMA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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