Article
Genetic epidemiology of glioblastoma multiforme: confirmatory and new findings from analyses of human leukocyte antigen alleles and motifs.
PloS one - 23 Sept 2009
Song Wei, Ruder Avima M, Hu Liangyuan, Li Yufeng, Ni Rong, Shao Wenshuo, Kaslow Richard A, Butler MaryAnn, Tang Jianming
Abstract excerpt
BACKGROUND: Human leukocyte antigen (HLA) class I genes mediate cytotoxic T-lymphocyte responses and natural killer cell function. In a previous study, several HLA-B and HLA-C alleles and haplotypes were positively or negatively associated with the occurrence and prognosis of glioblastoma multiforme (GBM). METHODOLOGY/PRINCIPAL FINDINGS: As an extension of the Upper Midwest Health Study, we have performed HLA...
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