Article

Functional germline variants in DNA damage repair pathways are associated with altered survival in adults with glioma treated with temozolomide

2023-10-15

Abstract excerpt

<h4>Background</h4> Temozolomide (TMZ) treatment has demonstrated, but variable, impact on glioma prognosis. This study examines associations of survival with DNA repair gene germline polymorphisms among glioma patients who did and did not have TMZ treatment. Identifying genetic markers which sensitize tumor cells to TMZ could personalize therapy and improve outcomes. <h4>Methods</h4> We evaluated TMZ-related surv...

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Literature Corpus work: 59a85d92-665e-502a-933d-8d20346ae914
DOI: 10.1101/2023.10.13.23296963

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