Article
pulver: an R package for parallel ultra-rapid p-value computation for linear regression interaction terms.
BMC bioinformatics - 29 Sept 2017
Molnos Sophie, Baumbach Clemens, Wahl Simone, Müller-Nurasyid Martina, Strauch Konstantin, Wang-Sattler Rui, Waldenberger Melanie, Meitinger Thomas, Adamski Jerzy, Kastenmüller Gabi, Suhre Karsten, Peters Annette, Grallert Harald, Theis Fabian J, Gieger Christian
Abstract excerpt
BACKGROUND: Genome-wide association studies allow us to understand the genetics of complex diseases. Human metabolism provides information about the disease-causing mechanisms, so it is usual to investigate the associations between genetic variants and metabolite levels. However, only considering genetic variants and their effects on one trait ignores the possible interplay between different "omics" layers....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.