Article
Identifying gene-gene interactions that are highly associated with four quantitative lipid traits across multiple cohorts.
Human genetics - 1 Feb 2017
De Rishika, Verma Shefali S, Holzinger Emily, Hall Molly, Burt Amber, Carrell David S, Crosslin David R, Jarvik Gail P, Kuivaniemi Helena, Kullo Iftikhar J, Lange Leslie A, Lanktree Matthew B, Larson Eric B, North Kari E, Reiner Alex P, Tragante Vinicius, Tromp Gerard, Wilson James G, Asselbergs Folkert W, Drenos Fotios, Moore Jason H, Ritchie Marylyn D, Keating Brendan, Gilbert-Diamond Diane
Abstract excerpt
Genetic loci explain only 25-30 % of the heritability observed in plasma lipid traits. Epistasis, or gene-gene interactions may contribute to a portion of this missing heritability. Using the genetic data from five NHLBI cohorts of 24,837 individuals, we combined the use of the quantitative multifactor dimensionality reduction (QMDR) algorithm with two SNP-filtering methods to exhaustively search for SNP-SNP...
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