Article
Primary Capreomycin Resistance Is Common and Associated With Early Mortality in Patients With Extensively Drug-Resistant Tuberculosis in KwaZulu-Natal, South Africa.
Journal of acquired immune deficiency syndromes (1999) - 15 Aug 2015
OʼDonnell Max R, Pillay Melendhran, Pillay Manormoney, Werner Lise, Master Iqbal, Wolf Allison, Mathema Barun, Coovadia Yacoob M, Mlisana Koleka, Horsburgh Charles Robert, Padayatchi Nesri
Abstract excerpt
BACKGROUND: Capreomycin is a key antimycobacterial drug in treatment of extensively drug-resistant tuberculosis (XDR-TB). Drug-susceptibility testing (DST) for capreomycin is not routinely performed in newly diagnosed XDR-TB in South Africa. We performed this study to assess the prevalence, clinical significance, and molecular epidemiology of capreomycin resistance in newly diagnosed patients with XDR-TB in...
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