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Article

Identification of novel single nucleotide variants in the drug resistance mechanism of Mycobacterium tuberculosis isolates by whole-genome analysis.

BMC genomics - 14 May 2024

Qian Weiye, Ma Nan, Zeng Xi, Shi Mai, Wang Mingqiang, Yang Zhiyuan, Tsui Stephen Kwok-Wing

Abstract excerpt

BACKGROUND: Tuberculosis (TB) represents a major global health challenge. Drug resistance in Mycobacterium tuberculosis (MTB) poses a substantial obstacle to effective TB treatment. Identifying genomic mutations in MTB isolates holds promise for unraveling the underlying mechanisms of drug resistance in this bacterium. METHODS: In this study, we investigated the roles of single nucleotide variants (SNVs) in MTB...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38745294
DOI: 10.1186/s12864-024-10390-3
PMCID: PMC11094924

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