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Article

Inference of relationships in population data using identity-by-descent and identity-by-state.

PLoS genetics - 1 Sept 2011

Stevens Eric L, Heckenberg Greg, Roberson Elisha D O, Baugher Joseph D, Downey Thomas J, Pevsner Jonathan

Abstract excerpt

It is an assumption of large, population-based datasets that samples are annotated accurately whether they correspond to known relationships or unrelated individuals. These annotations are key for a broad range of genetics applications. While many methods are available to assess relatedness that involve estimates of identity-by-descent (IBD) and/or identity-by-state (IBS) allele-sharing proportions, we developed...

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PMID: 21966277
DOI: 10.1371/journal.pgen.1002287
PMCID: PMC3178600

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