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Article

NGSremix: a software tool for estimating pairwise relatedness between admixed individuals from next-generation sequencing data.

G3 (Bethesda, Md.) - 7 Aug 2021

Nøhr Anne Krogh, Hanghøj Kristian, Garcia-Erill Genís, Li Zilong, Moltke Ida, Albrechtsen Anders

Abstract excerpt

Estimation of relatedness between pairs of individuals is important in many genetic research areas. When estimating relatedness, it is important to account for admixture if this is present. However, the methods that can account for admixture are all based on genotype data as input, which is a problem for low-depth next-generation sequencing (NGS) data from which genotypes are called with high uncertainty. Here,...

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PMID: 34015083
DOI: 10.1093/g3journal/jkab174
PMCID: PMC8496226

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