Article
Assessing the resolution of extended pedigrees using hybridization capture SNP panels: Evidence from real and simulated data.
Forensic science international. Genetics - 1 Jun 2026
Shan Tiantian, Mao Zhigang, Wang Haoyu, Wei Yifan, Zhang Jiarong, Hou Tingyun, Li Jiawen, Wang Chu, Jin Yuntian, Zhang Yuhao, Zhu Qiang, Ni Ming, Zhang Ji
Abstract excerpt
Accurate inference of distant biological relationships remains challenging in forensic genetics. Here, we evaluated a hybridization capture SNP panel for high-resolution pairwise kinship analysis using two extended Han Chinese pedigrees (93 individuals, first to sixth degree). A total of 6049 high-quality autosomal SNPs were obtained, and kinship inference was performed using LR-based and IBS-based methods....
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