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Article

Estimating kinship in admixed populations.

American journal of human genetics - 13 Jul 2012

Thornton Timothy, Tang Hua, Hoffmann Thomas J, Ochs-Balcom Heather M, Caan Bette J, Risch Neil

Abstract excerpt

Genome-wide association studies (GWASs) are commonly used for the mapping of genetic loci that influence complex traits. A problem that is often encountered in both population-based and family-based GWASs is that of identifying cryptic relatedness and population stratification because it is well known that failure to appropriately account for both pedigree and population structure can lead to spurious...

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PMID: 22748210
DOI: 10.1016/j.ajhg.2012.05.024
PMCID: PMC3397261

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