Article
A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer.
Nature genetics - 1 Sept 2015
Aminkeng Folefac, Bhavsar Amit P, Visscher Henk, Rassekh Shahrad R, Li Yuling, Lee Jong W, Brunham Liam R, Caron Huib N, van Dalen Elvira C, Kremer Leontien C, van der Pal Helena J, Amstutz Ursula, Rieder Michael J, Bernstein Daniel, Carleton Bruce C, Hayden Michael R, Ross Colin J D
Abstract excerpt
Anthracyclines are used in over 50% of childhood cancer treatment protocols, but their clinical usefulness is limited by anthracycline-induced cardiotoxicity (ACT) manifesting as asymptomatic cardiac dysfunction and congestive heart failure in up to 57% and 16% of patients, respectively. Candidate gene studies have reported genetic associations with ACT, but these studies have in general lacked robust patient...
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