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Article

Risk of anthracycline-induced cardiac dysfunction in adolescent and young adult (AYA) cancer survivors: role of genetic susceptibility loci.

The pharmacogenomics journal - 29 Jun 2024

Stafford Lily K, Tang Xiaohui, Brandt Amanda, Ma Jianzhong, Banchs Jose, Livingston J Andrew, Roth Michael E, Morrison Alanna C, Hildebrandt Michelle A T

Abstract excerpt

There is a known genetic susceptibility to anthracycline-induced cardiac dysfunction in childhood cancer survivors, but this has not been adequately shown in adolescent and young adult (AYA) patients. Our aim was to determine if the previously identified variants associated with cardiac dysfunction in childhood cancer patients affect AYA cancer patients similarly. Forty-five variants were selected for analysis in...

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Share to Anthracyclines
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38951505
DOI: 10.1038/s41397-024-00343-0
PMCID: PMC11824427

Genes

HAS3
RARG
SLC10A2
SLC22A17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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