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Article

Genome-wide association study of genetic variants related to anthracycline-induced cardiotoxicity in early breast cancer.

Cancer science - 1 Jul 2020

Park Boram, Sim Sung Hoon, Lee Keun Seok, Kim Hak Jin, Park In Hae

Abstract excerpt

We performed a genome-wide association study to investigate the association between single nucleotide polymorphisms and anthracycline-induced cardiotoxicity (ACT) in patients diagnosed with early breast cancer. From January 2000 to December 2015, 8490 patients underwent breast surgery at the National Cancer Center in Korea. Patients who received doxorubicin (cumulative dose 240 mg/m2 -300 mg/m2 ) with or without...

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PMID: 32378780
DOI: 10.1111/cas.14446
PMCID: PMC7385356

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