A functional variant in MIR4300HG, the host gene of microRNA MIR4300 is associated with progression of adolescent idiopathic scoliosis.

doi:10.1093/hmg/ddx291

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A functional variant in MIR4300HG, the host gene of microRNA MIR4300 is associated with progression of adolescent idiopathic scoliosis.

Human molecular genetics - 15 Oct 2017

Ogura Yoji, Kou Ikuyo, Takahashi Yohei, Takeda Kazuki, Minami Shohei, Kawakami Noriaki, Uno Koki, Ito Manabu, Yonezawa Ikuho, Kaito Takashi, Yanagida Haruhisa, Watanabe Kei, Taneichi Hiroshi, Harimaya Katsumi, Taniguchi Yuki, Kotani Toshiaki, Tsuji Taichi, Suzuki Teppei, Sudo Hideki, Fujita Nobuyuki, Yagi Mitsuru, Chiba Kazuhiro, Kubo Michiaki, Kamatani Yoichiro, Nakamura Masaya, Matsumoto Morio, Watanabe Kota, Ikegawa Shiro

Abstract excerpt

Adolescent idiopathic scoliosis (AIS) is a common spinal deformity affecting millions of children. Since treatment and prognosis of AIS depend on curve progression, identifying factors related to AIS curve progression is important in its management. Although several genetic loci for AIS occurrence are reported, no locus for curve progression has been identified. To identify genes associated with AIS progression,...

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PMID: 29016859
DOI: 10.1093/hmg/ddx291

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