Longitudinal Cell-Free DNA Analysis in Patients with Small Cell Lung Cancer Reveals Dynamic Insights into Treatment Efficacy and Disease Relapse.

doi:10.1016/j.jtho.2017.09.1951

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Article

Longitudinal Cell-Free DNA Analysis in Patients with Small Cell Lung Cancer Reveals Dynamic Insights into Treatment Efficacy and Disease Relapse.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jan 2018

Almodovar Karinna, Iams Wade T, Meador Catherine B, Zhao Zhiguo, York Sally, Horn Leora, Yan Yingjun, Hernandez Jennifer, Chen Heidi, Shyr Yu, Lim Lee P, Raymond Christopher K, Lovly Christine M

Abstract excerpt

INTRODUCTION: Patients with SCLC have a poor prognosis and limited treatment options. Because access to longitudinal tumor samples is very limited in patients with this disease, we chose to focus our studies on the characterization of plasma cell-free DNA (cfDNA) for rapid, noninvasive monitoring of disease burden. METHODS: We developed a liquid biopsy assay that quantifies somatic variants in cfDNA. The assay...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28951314
DOI: 10.1016/j.jtho.2017.09.1951
PMCID: PMC5827950

Genes

KIT
BRAF
MYC
NOTCH1
NOTCH2
NOTCH3
NOTCH4
PTEN
FGFR1
MYCN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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