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Dynamics of Sequence and Structural Cell-Free DNA Landscapes in Small-Cell Lung Cancer

18 Apr 2023

Abstract excerpt

PURPOSE: Patients with small-cell lung cancer (SCLC) have an exceptionally poor prognosis, calling for improved real-time noninvasive biomarkers of therapeutic response. EXPERIMENTAL DESIGN: We performed targeted error-correction sequencing on 171 serial plasmas and matched white blood cell (WBC) DNA from 33 patients with metastatic SCLC who received treatment with chemotherapy (n = 16) or...

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PMID: 37071497
DOI: 10.1158/1078-0432.ccr-22-2242

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