Article
Circulating Tumor DNA Profiling in Small-Cell Lung Cancer Identifies Potentially Targetable Alterations.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2019
Devarakonda Siddhartha, Sankararaman Sumithra, Herzog Brett H, Gold Kathryn A, Waqar Saiama N, Ward Jeffrey P, Raymond Victoria M, Lanman Richard B, Chaudhuri Aadel A, Owonikoko Taofeek K, Li Bob T, Poirier John T, Rudin Charles M, Govindan Ramaswamy, Morgensztern Daniel
Abstract excerpt
PURPOSE: Patients with SCLC rarely undergo biopsies at relapse. When pursued, tissue obtained can be inadequate for molecular testing, posing a challenge in identifying potentially targetable alterations in a clinically meaningful time frame. We examined the feasibility of circulating tumor DNA (ctDNA) testing in identifying potentially targetable alterations in SCLC. EXPERIMENTAL DESIGN: ctDNA test results were...
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