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Article

Melanocortin 1 receptor (MC1R) polymorphisms' influence on size and dermoscopic features of nevi.

Pigment cell & melanoma research - 1 Jan 2018

Vallone María Gabriela, Tell-Marti Gemma, Potrony Miriam, Rebollo-Morell Aida, Badenas Celia, Puig-Butille Joan Anton, Gimenez-Xavier Pol, Carrera Cristina, Malvehy Josep, Puig Susana

Abstract excerpt

The melanocortin 1 receptor (MC1R) is a highly polymorphic gene. The loss-of-function MC1R variants ("R") have been strongly associated with red hair color phenotype and an increased melanoma risk. We sequenced the MC1R gene in 175 healthy individuals to assess the influence of MC1R on nevus phenotype. We identified that MC1R variant carriers had larger nevi both on the back [p-value = .016, adjusted for multiple...

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Identifiers

PMID: 28950052
DOI: 10.1111/pcmr.12646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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