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Article

The gain of function of p53 mutant p53S in promoting tumorigenesis by cross-talking with H-RasV12.

International journal of biological sciences - 1 Jan 2012

Jia Shuting, Zhao Lanjun, Tang Wenru, Luo Ying

Abstract excerpt

The loss of wild type p53 tumor suppressive function and oncogenic gain-of-function of p53 mutants have been showing important implications in tumorigenesis. The p53(N236S) (p53(N239S) in human, p53S) mutation has been shown to lose wild type p53 function by yeast assay. However, its gain of func...

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Share to Cell Cycle Checkpoints
Share to Cell Transformation, Neoplastic
Share to Cyclin-Dependent Kinase Inhibitor p21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoretic Mobility Shift Assay

Share to Genes, ras

Share to Mice, SCID

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Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 22553460
DOI: 10.7150/ijbs.4176
PMCID: PMC3341601

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22553460-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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