Article
Carbon monoxide poisoning is prevented by the energy costs of conformational changes in gas-binding haemproteins.
Proceedings of the National Academy of Sciences of the United States of America - 20 Sept 2011
Antonyuk Svetlana V, Rustage Neil, Petersen Christine A, Arnst Jamie L, Heyes Derren J, Sharma Raman, Berry Neil G, Scrutton Nigel S, Eady Robert R, Andrew Colin R, Hasnain S Samar
Abstract excerpt
Carbon monoxide (CO) is a product of haem metabolism and organisms must evolve strategies to prevent endogenous CO poisoning of haemoproteins. We show that energy costs associated with conformational changes play a key role in preventing irreversible CO binding. AxCYTcp is a member of a family of haem proteins that form stable 5c-NO and 6c-CO complexes but do not form O(2) complexes. Structure of the AxCYTcp-CO...
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