Article
Insights into the reactivation of cobalamin-dependent methionine synthase.
Proceedings of the National Academy of Sciences of the United States of America - 3 Nov 2009
Koutmos Markos, Datta Supratim, Pattridge Katherine A, Smith Janet L, Matthews Rowena G
Abstract excerpt
Cobalamin-dependent methionine synthase (MetH) is a modular protein that catalyzes the transfer of a methyl group from methyltetrahydrofolate to homocysteine to produce methionine and tetrahydrofolate. The cobalamin cofactor, which serves as both acceptor and donor of the methyl group, is oxidized once every approximately 2,000 catalytic cycles and must be reactivated by the uptake of an electron from reduced...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.