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Article

Ephrin-B3 coordinates timed axon targeting and amygdala spinogenesis for innate fear behaviour.

Nature communications - 24 Mar 2016

Zhu Xiao-Na, Liu Xian-Dong, Sun Suya, Zhuang Hanyi, Yang Jing-Yu, Henkemeyer Mark, Xu Nan-Jie

Abstract excerpt

Innate emotion response to environmental stimuli is a fundamental brain function that is controlled by specific neural circuits. Dysfunction of early emotional circuits may lead to neurodevelopmental disorders such as autism and schizophrenia. However, how the functional circuits are formed to prime initial emotional behaviours remain elusive. We reveal here using gene-targeted mutations an essential role for...

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PMID: 27008987
DOI: 10.1038/ncomms11096
PMCID: PMC4820848

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