Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

APE1/Ref-1 Inhibits Phosphate-Induced Calcification and Osteoblastic Phenotype Changes in Vascular Smooth Muscle Cells.

International journal of molecular sciences - 25 Sept 2017

Lee Ki Mo, Lee Eun Ok, Lee Yu Ran, Joo Hee Kyoung, Park Myoung Soo, Kim Cuk-Seong, Choi Sunga, Jeong Jin-Ok, Jeon Byeong Hwa

Abstract excerpt

Vascular calcification plays a role in the pathogenesis of atherosclerosis, diabetes, and chronic kidney disease; however, the role of apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) in inorganic phosphate (Pi)-induced vascular smooth muscle cell (VSMC) calcification remains unknown. In this study, we investigated the possible role of APE1/Ref-1 in Pi-induced VSMC calcification. We observed that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcification, Physiologic
Share to DNA-(Apurinic or Apyrimidinic Site) Lyase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Silencing

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Osteoblasts

Share to Phosphates

Share to Vascular Calcification

Source

Open in PubMed Open full text

Identifiers

PMID: 28946662
DOI: 10.3390/ijms18102053
PMCID: PMC5666735

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

APE1/Ref-1 Inhibits Phosphate-Induced Calcification and Osteoblastic Phenotype Changes in Vascular Smooth Muscle Cells.PMID 28946662Read ↗

Direct effects of phosphate on vascular cell function.Semantic proximity Read ↗

The molecular biology and pathophysiology of vascular calcification.Semantic proximity Read ↗

Sp1 Plays an Important Role in Vascular Calcification Both In Vivo and In Vitro.Semantic proximity Read ↗

Key regulators of vascular calcification in chronic kidney disease: Hyperphosphatemia, BMP2, and RUNX2Semantic proximity Read ↗

Vascular calcification is coupled with phenotypic conversion of vascular smooth muscle cells through Klf5-mediated transactivation of the Runx2 promoter.Semantic proximity Read ↗

Vascular calcification in CKD: New insights into its mechanismsSemantic proximity Read ↗

Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness.Semantic proximity Read ↗

Kruppel-like factor 4 contributes to high phosphate-induced phenotypic switching of vascular smooth muscle cells into osteogenic cells.Semantic proximity Read ↗

Roles of Histone Acetylation Modifiers and Other Epigenetic Regulators in Vascular CalcificationSemantic proximity Read ↗

KAP1 modulates osteogenic differentiation via the ERK/Runx2 cascade in vascular smooth muscle cellsSemantic proximity Read ↗

BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells.Semantic proximity Read ↗

APE1/Ref-1 redox function prevents VSMC phenotypic switching through KLF4 suppression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.