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Article

Sp1 Plays an Important Role in Vascular Calcification Both In Vivo and In Vitro.

Journal of the American Heart Association - 23 Mar 2018

Zhang Xinyu, Li Rui, Qin Xiaoteng, Wang Lei, Xiao Jie, Song Yu, Sheng Xi, Guo Mengqi, Ji Xiaoping

Abstract excerpt

BACKGROUND: Vascular calcification and increased cardiovascular morbidity and mortality are closely related in patients with end-stage renal disease and diabetes mellitus. Specific protein 1 (Sp1) is a transactivation molecule that plays a crucial role in the regulation of apoptosis, fibrosis, angiogenesis, and other pathological disorders. There is evidence that specific protein 1 (Sp1) directly stimulates the...

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Identifiers

PMID: 29572322
DOI: 10.1161/JAHA.117.007555
PMCID: PMC5907546

Genes

BMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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