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Article

Vascular calcification is coupled with phenotypic conversion of vascular smooth muscle cells through Klf5-mediated transactivation of the Runx2 promoter.

Bioscience reports - 4 Nov 2014

Zhang Jing, Zheng Bin, Zhou Pei-Pei, Zhang Ruo-Nan, He Ming, Yang Zhan, Wen Jin-Kun

Abstract excerpt

Both Klf5 (Krüppel-like factor 5) and Runx2 are involved in phenotypic switching of VSMC (vascular smooth muscle cells). However, the potential link between Klf5 and Runx2 in mediating vascular calcification remains unclear. The aim of the present study was to elucidate the actual relationship between Klf5 and Runx2 in mediating VSMC calcification. We found that high Pi (phosphate) increased the expression of...

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Identifiers

PMID: 25205373
DOI: 10.1042/BSR20140103
PMCID: PMC4219426

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