Article
Alterations in potential sites for glycosylation predominate during evolution of the simian immunodeficiency virus envelope gene in macaques.
Journal of virology - 1 Oct 1992
Overbaugh J, Rudensey L M
Abstract excerpt
Genetic diversity is a hallmark of the human immunodeficiency virus (HIV) genome, but the role of distinct HIV variants in the development of AIDS is unclear. Envelope (env) is the most highly variable gene in HIV as well as in other retroviruses. We have previously demonstrated that variation in simian immunodeficiency virus (SIV) env is primarily localized in two regions (V1 and V4) during progression to simian...
Topics
- Amino Acid Sequence
- Animals
- Cloning, Molecular
- DNA, Viral
- Gene Products, env
- Genes, Viral
- Genetic Variation
- Glycosylation
- Macaca nemestrina
- Molecular Sequence Data
- Mutation