Article
Variation in simian immunodeficiency virus env is confined to V1 and V4 during progression to simian AIDS.
Journal of virology - 1 Dec 1991
Overbaugh J, Rudensey L M, Papenhausen M D, Benveniste R E, Morton W R
Abstract excerpt
We have monitored changes in the simian immunodeficiency virus (SIV) envelope (env) gene in two macaques which developed AIDS after inoculation with a molecular clone of SIV. As the animals progressed to AIDS, selection occurred for viruses with variation in two discrete regions (V1 and V4) but n...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Genes, env
- Genetic Variation
- Lymphocytes
- Macaca mulatta
- Molecular Sequence Data
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction
- Sequence Homology, Nucleic Acid
- Simian Acquired Immunodeficiency Syndrome
- Simian Immunodeficiency Virus