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Article

Variation in simian immunodeficiency virus env is confined to V1 and V4 during progression to simian AIDS.

Journal of virology - 1 Dec 1991

Overbaugh J, Rudensey L M, Papenhausen M D, Benveniste R E, Morton W R

Abstract excerpt

We have monitored changes in the simian immunodeficiency virus (SIV) envelope (env) gene in two macaques which developed AIDS after inoculation with a molecular clone of SIV. As the animals progressed to AIDS, selection occurred for viruses with variation in two discrete regions (V1 and V4) but not for viruses with changes in the region of SIV env that corresponds to the immunodominant, V3 loop of human...

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Identifiers

PMID: 1942255
DOI: 10.1128/JVI.65.12.7025-7031.1991
PMCID: PMC250821

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