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Article

BRG1 and BRM function antagonistically with c-MYC in adult cardiomyocytes to regulate conduction and contractility.

Journal of molecular and cellular cardiology - 1 Apr 2017

Willis Monte S, Holley Darcy Wood, Wang Zhongjing, Chen Xin, Quintana Megan, Jensen Brian C, Tannu Manasi, Parker Joel, Jeyaraj Darwin, Jain Mukesh K, Wolfram Julie A, Lee Hyoung-Gon, Bultman Scott J

Abstract excerpt

RATIONALE: The contractile dysfunction that underlies heart failure involves perturbations in multiple biological processes ranging from metabolism to electrophysiology. Yet the epigenetic mechanisms that are altered in this disease state have not been elucidated. SWI/SNF chromatin-remodeling complexes are plausible candidates based on mouse knockout studies demonstrating a combined requirement for the BRG1 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28232072
DOI: 10.1016/j.yjmcc.2017.02.003
PMCID: PMC5415084

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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BRG1 and BRM function antagonistically with c-MYC in adult cardiomyocytes to regulate conduction and contractility.PMID 28232072Read ↗

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