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Article

RNA-Seq Profiling Reveals Transcriptional Changes in Phosphorylation-Site Mutants of Brg1.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jul 2026

Kimura Ayuko, Nakabayashi Jun, Ohara Osamu, Kimura Yayoi

Abstract excerpt

Brg1 is a core ATPase subunit of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complex that regulates DNA accessibility for RNA polymerase II (Pol II), transcription factors, and DNA repair enzymes. Phosphoproteomic profiling of highly malignant ovarian clear cell carcinoma (OCCC) cell lines revealed reduced levels of several SWI/SNF components and decreased Brg1 phosphorylation within its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42469951
DOI: 10.1111/gtc.70137
PMCID: PMC13379595

Genes

BCL2
FGFR2
NFKBIA
ZC3H12A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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