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Article

Isoprenylcysteine carboxylmethyltransferase is required for the impact of mutant KRAS on TAZ protein level and cancer cell self-renewal.

Oncogene - 1 Jul 2020

Chai Tin Fan, Manu Kanjoormana Aryan, Casey Patrick J, Wang Mei

Abstract excerpt

Cancer stem cells possess the capacity for self-renewal and resistance to chemotherapy. It is therefore crucial to understand the molecular regulators of stemness in the quest to develop effective cancer therapies. TAZ is a transcription activator that promotes stem cell functions in post-development mammalian cells; suppression of TAZ activity reduces or eliminates cancer stemness in select cancers....

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PMID: 32561852
DOI: 10.1038/s41388-020-1364-7
PMCID: PMC7391290

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